Boltes, K. and Rosal, R. and García-Calvo, E. (2012) Toxicity of mixtures of perfluorooctane sulphonic acid with chlorinated chemicals and lipid regulators. Chemosphere, 86 (1). pp. 24-29. ISSN 00456535
Full text not available from this repository.Abstract
The toxicological interaction of perfluorooctane sulphonic acid (PFOS) with the chlorinated pollutants triclosan and 2,4,6-trichlorophenol and the lipid regulators gemfibrozil and bezafibrate was evaluated using the combination index-isobologram equation. The endpoint for bioassays was the growth rate inhibition of the green alga Pseudokirchneriella subcapitata. The results showed that most of the binary combinations assayed exhibited antagonism at all effect levels. The addition of a third component induced a less antagonistic or even synergistic behaviour. This was particularly marked for the ternary mixture of triclosan and 2,4,6-trichlorophenol with PFOS, for which synergism was very strong at all effect levels, with a combination index as low as 0.034 ± 0.002 at EC(50) for the mixture. The results obtained indicate that the evaluation of mixture toxicity from single component data using the concentration addition approach could severely underestimate combined toxicity.
| Item Type: | Article |
|---|---|
| Additional Information: | Epub 2011 Sep 23 |
| Uncontrolled Keywords: | Perfluorooctane sulphonic acid; Chlorinated compounds; Fibrates; Pseudokirchneriellasubcapitata; Combination index |
| Subjects: | T Technology > TD Environmental technology. Sanitary engineering T Technology > TP Chemical technology |
| Depositing User: | José Ángel Gómez Martín |
| Date Deposited: | 02 Apr 2013 15:14 |
| Last Modified: | 02 Apr 2013 15:14 |
| URI: | http://eprints.imdea-agua.org:13000/id/eprint/86 |
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